- Also known as histiocytic necrotizing lymphadenitis & Kikuchi-Fujimoto disease.
- Clinically non-cancerous enlargement of the lymph nodes.
- First described in Japan by Dr Masahiro Kikuchi in 1972, & also independently by Y. Fujimoto.
Epidemiology:
- Very rare disease mainly seen in Japan.
- There have been isolated cases are reported in America, Europe & Asia.
- Mainly a disease of young adults (mean age, 20–30 years).
- Female preponderance.
Aetiology:
- Cause of this disease is unknown.
- Proposed infectious & autoimmune causes.
- Possible genetic predisposition.
- Suspected infectious candidates include - CMV, EBV, HSV, Varicella zoster virus, parainfluenza virus, parvovirus B19, paramyxovirus.
Clinical:
- Clinical features include - fever, lymphadenopathy, skin rashes and headache.
- Occasionally there may be features of hepatosplenomegaly or meningitis.
- Laboratory findings include leucopenia, atypical lymphocytes & raised ESR.
- Course of the disease is generally benign & self-limiting.
- Lymphadenopathy most often resolves over weeks to 6 months.
- Around 3% recurrence rate.
- Death is very rare - from hepatic, respiratory, or cardiac failure.
Diagnosis:
- Based on histology of lymph node showing necrotizing lymphadenitis.
Differential Diagnosis:
- Other causes of lymphadenopathy
- Cat-scratch fever
- CMV infection
- Disseminated tuberculosis
- Fungal infections
- HIV infection
- Lymphoma
- Sarcoidosis
- SLE
- Toxoplasmosis
- Viral lymphadenitis
Tags: Histiocytic Necrotizing Lymphadenitis - Kikuchi's Disease - Kikuchi-Fujimoto Disease
Posted by Medicalchemy
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Posted by Medicalchemy
Medicalchemy Group: History of Medicine - Images - Mnemonics - Syndromes - Acute Medicine - Anaesthesiology - Anatomy - Anthropology - Biochemistry - Cardiology - Dentistry -Dermatology - Drug ADR - Drugs - Embryology - Emergency Medicine - Endocrinology - Epidemiology - Family Medicine - Forensic Medicine - Gastroenterology - Genes - Genetics - Geriatrics -Gynecology - Haematology - Health Informatics - Hepatology - Immunology - Infection - Intensive Care - Medical Dictionary - Medical Education - Medical Statistics - Metabolic Medicine -Microbiology - Nephrology - Neuroanatomy - Neuroscience - Nuclear Medicine - Nutrition - Obstetrics - Occupational Health - Oncology - Ophthalmology - Orthopaedics - Otolaryngology -Paediatrics - Palliative Care - Parasitology - Pathology - Pharmacology - Physiology - Proteomics - Psychiatry - Public Health - Radiology - Respiratory - Rehabilitation - Rheumatology -Sports Medicine - Surgery - Toxicology - Tropical Medicine - Urology - Vascular - Virology.
